Background: To compare the efficacy and safety of timolol 0.5% versus brinzolamide 1.0% when added to travoprost monotherapy in patients with primary open-angle glaucoma or ocular hypertension. Methods: Patients meeting selection criteria (IOP one eye 19 mmHg and ≤32 mmHg and IOP both eyes ≤32 mmHg at 8:00 h) were switched to travoprost monotherapy for 4 weeks. Mainz, Renânia-Palatinado, Alemanha: Presidente Georg Krausch Total de estudantes: 37 039 Página oficial website oficial: A Universidade Johannes Gutenberg de Mainz (em alemão: Johannes Gutenberg-Universität Mainz) é uma instituição de ensino superior localizada em Mainz, no estado da Renânia-Palatinado, Alemanha. J Neurosci 34(5):1924-31. Proceedings of the National Academy of … Additional information about this page. J Neurosci 15:1109-1113. Evers JF, Muench D, Duch C (2006) Developmental relocation of presynaptic terminals along distinct types of dendritic filopodia. Brembs B, Christiansen F, Pflueger HJ, Duch C (2007) Flight initiation and maintenance deficits in flies with genetically altered biogenic amine levels. Toplinks. Mit Erfahrungsberichten, NC-Liste und zulassungsfreien Studiengängen. Die rechteckige Kernburg ist von vier Gebäudeflügeln und einer Schildmauer mit Ecktürmen umgeben. Besucheranschrift / Office: Hanns-Dieter-Hüsch-Weg 15 (Gebäude 1578, 2.Stock, 02-352) 55128 Mainz Disease Models & Mechanisms, Dec 3 [Epub ahead of print]. Libersat F, Duch C (2002) Morphometric analysis of dendritic remodeling in an identified motoneuron during postembryonic development. J Comp Neurol, 518:2437-2455. Institute of Neurobiology, Johannes Gutenberg University of Mainz, 55099 Mainz, Germany. J Neurophysiol 93:2331-2342. J Comp Physiol A: 196(1):37-50. Ryglewski S, Pflueger HJ, Duch C (2007) Expanding the Neuron’s Calcium Signaling Repertoire: Intracellular Calcium Release via Voltage induced PLC and IP3R Activation. Institute of Neurobiology, Johannes Gutenberg University of Mainz, 55099 Mainz, Germany cduch@uni-mainz.de. Neuron 93(3):632-645.e6. J Comp Physiol A: 195(3):265-77. Lukas Kilo, Ph.D. Student, kilo@uni-mainz.de Meseke M, Evers JF, Duch C (2009) PTX-induced hyperexcitability affects dendritic shape and GABAergic synapse density but not synapse distribution during Manduca postembryonic motoneuron development. Mainz é uma cidade independente ( kreisfreie Stadt ) ou distrito urbano ( Stadtkreis ), ou seja, possui estatuto de distrito ( … Ryglewski S, Vonhoff F, Scheckel K, Duch C (2017) Intra-neuronal Competition for Synaptic Partners Conserves the Amount of Dendritic Building Material. Dev Biol 231:348-363. Ryglewski S, Duch C, Altenhein B (2017) Tyramine Actions on Drosophila Flight Behavior Are Affected by a Glial Dehydrogenase/Reductase. Arbeitsgruppe von der Theorie zur Forschungspraxis. (2018) Structural and Molecular Properties of Insect Type II Motor Axon Terminals. However, in a computing, adapting, and learning system such as the brain, these properties must also retain functional plasticity. Gaitanidis A, Dimitriadou A, Dowse H, Sanyal S, Duch C, Consoulas C. (2019) Longitudinal assessment of health-span and pre-death morbidity in wild type Drosophila. Current project. Ryglewski S, Duch C (2009) Shaker and Shal mediate transient calcium-independent potassium current in a Drosophila flight motoneuron. Burg Lahneck. ℹ️ mail.uni-mainz.de receives about 38,037 unique visitors per day, and it is ranked 25,698 in the world. Perturbations cause dendrite shifts and result in defects of adaptive motor control. Duch C, Levine RB (2000) Remodeling of membrane properties and dendritic architecture accompany the postembryonic conversion of a ‘slow’ into a ‘fast’ motoneuron. Ryglewski S, Duch C (2012) Preparation of Drosophila Central Neurons for in situ Patch Clamping. Each neuron must acquire a specific ‘Gestalt’ and a defined set of ion channels during development and maintain them within critical ranges throughout life. The biogenic amines octopamine (OA) and tyramine (TA) modulate insect motor behavior in an antagonistic manner. Look up the English to German translation of uni Mainz in the PONS online dictionary. Consequently, normal brain function relies on the correct regulation of single neuron properties, such as their synaptic connections, morphology, and … J Insect Physiol 54(1):240-54. Die Entfernung von Graffiti kostet die Johannes Gutenberg-Universität jährlich rund 80.000 Euro. To understand the adaptive regulation of these properties our research objectives are: • identify the molecular mechanisms that regulate electrical and morphological properties of neurons. J Neurophysiol 102:41-58. PLoS One, 7(2):e31835. 9.00-12.00) Tel. J Vis Exp 15;(68). Institute of Neurobiology, Johannes Gutenberg University of Mainz, Mainz, Germany. Ryglewski S, Lance K, Levine RB, Duch C (2012) Cav2 Channels Mediate LVA and HVA Calcium Currents in Drosophila Motoneurons. * Shared last author. eNeuro. Neurons are the building blocks of the brain. Group leader. The promotion and introduction of new ideas, the use of knowledge to improve people’s lives and encourage them to overcome the many boundaries they encounter daily – these are the underlying ambitions of Johannes Gutenberg University Mainz. J Neurophysiol 100(5):2525-36. Vonhoff F, Williams A, Ryglewski S, Duch C (2012) Drosophila as a Model for MeCP2 Gain of Function in Neurons. Brain Res Bulletin 53:571-583. Dev Biol 297(1):214-227. Includes free vocabulary trainer, verb tables and pronunciation function. Adrenergic signaling profoundly modulates animal behavior. Nove de Julho, 5229 - 5° Andar Neurons are the building blocks of the brain. • determine the functional consequences of correct and false regulation of neuronal properties for synaptic integration, neuronal firing patterns, and behavior in the healthy and in the diseased brain. Stefanie Ryglewski, Ph.D., ryglewsk@uni-mainz.de. Mol Neurobiol 29:303-320. Biogenic amines, like norepinephrine, can act as neuromodulators to render animal behavior adaptive to changing external and internal conditions. In addition to the unprecedented genetic tools available in Drosophila, the transformation from the larval to the adult stage during metamorphosis is a striking example of postembryonic nervous system plasticity and remodeling, and the functions of individually identified neurons can directly be related to stage specific behaviors. www.uni-mainz.de. We use the versatile genetic model system Drosophila melanogaster for our research. Hotline +49 6131 39-22122. Group (open) – Master Erziehungswissenschaft, Uni Mainz. J Neurophysiol 87:1415-1425. Ryglewski S, Kilo L, Duch C (2014) Sequential acquisition of cacophony calcium currents, sodium channels and voltage-dependent potassium currents affects spike shape and dendrite growth during postembryonic maturation of an identified Drosophila motoneuron Eur J Neurosci, 39(10):1572-85. Duch, Univ.-Prof. Dr. Carsten Address: Hanns-Dieter-Hüsch-Weg 15,55128 Mainz Building: BioZentrum I (1578) Room: 02-352 Phone: +49 6131 39 23419 Baudoux S, Duch C, Morris OT (1998) Coupling of efferent neuromodulatory neurons to rhythmical leg motor activity in the locust. Unravel Resilience - Using Multi-Omics Integration to explore the Molecular Background of Stress Resilience Resilience is the ability to cope with stress or to quickly recover to pre-crisis state after being exposed to extreme stress. Duch C, Pflueger HJ (1995) Motor patterns for horizontal and upside down walking and vertical climbing in the locust. Morris OT, Duch C, Stevenson PA (1999) Reflex activation of locust octopaminergic modulatory neurons by proprioreceptors responsive to flight muscle contractions. University Information Security and Privacy © 2020 The Arizona Board of Regents on behalf of The University of Arizona.The University of Arizona. J Neurosci 24:9826-9837. Libersat F, Duch C (2004) Cellular and molecular mechanisms of the maturation of neuronal dendritic trees. eNeuro. J Comp Neurol 422:1-17. E-Mail: joerg.korff@uni-mainz… Physiology (Bethesda) 26:293-303. Physiology, UM Mainz: Amparo Acker-Palmer Cell Biology, GU Frankfurt: Eva-Maria Albers Dept. J Comp Neurol 450:153-166. Schützler N, Girwert C, Hügli I, Mohana G, Roignant JY, Ryglewski S*, Duch C* (2019) Tyramine action on motoneuron excitability and adaptable tyramine/octopamine ratios adjust Drosophila locomotion to nutritional state. Somos uma instituição de Educação que atua nas áreas de Treinamento em Desenvolvimento Profissional e Gerencial desde fevereiro de 2003. DEGREE COURSE: Guide to the Bachelors and Masters Degree Programs Hohensee S, Bleiss W, Duch C (2008) Correlative electron and confocal microscopy assessment of synapse localization in the central nervous system of an insect. Group (closed) – BA Erziehungswissenschaften, Uni Mainz. Please note: Due to the amount of requests reaching the “Studierendenservice” at the moment there is a delay up to one week in answering them. University Medical Center Mainz | 2,450 followers on LinkedIn. Duch C, Mentel T (2004) Activity affects dendritic shape and synapse elimination during steroid induced dendritic regression in Manduca sexta. Acta Biol Hung 55:3-12. doi: 10.1523/ENEURO.0181-19.2019. Duch C, Vonhoff F, Ryglewski S (2008) Dendrite elongation and dendritic branching are affected separately by different forms of intrinsic motoneuron excitability. Gaitanidis A, Dimitriadou A, Dowse H, Sanyal S, Duch C, Consoulas C. (2019) Longitudinal assessment of health-span and pre-death morbidity in wild type Drosophila. eBook - JaSeAn. Duch C, Pflueger HJ (1999) DUM neurons in locust flight: a model system for amine mediated peripheral adjustments to a central motor program. Pflueger HJ, Duch C (2011) Dynamic neural control of insect muscle metabolism related to motor behavior. Kühn C, Duch C (2013) Putative Excitatory and Putative Inhibitory Inputs Localize to Different Dendritic Domains in a Drosophila Flight Motoneuron. The Ernst Florey memory lecture. Johannes Gutenberg-Universität Mainz Jakob-Welder-Weg 9 55099 Mainz. Biozentrum 1 Hanns-Dieter-Hüsch-Weg 15, 2nd Floor, Room 02.356 D 55128 Mainz Mo. Group (private) – Master of Education, Uni Mainz. Consequently, normal brain function relies on the correct regulation of single neuron properties, such as their synaptic connections, morphology, and membrane currents. J Comp Neurol 403:119-134. Fax +49 6131 39-25548. Fields L, Duch C, Pflueger HJ (2007) Reflex activation of octopaminergic unpaired median neurons in the locust. Mentel T, Duch C, Müller U, Stypa H, Wegener G, Pflueger HJ (2003) Fuel selection in locust flight muscle by the activity of central modulatory neurons. The University of Mainz (full name Johannes Gutenberg University Mainz) (German: Johannes Gutenberg-Universität Mainz) is a public research university in Mainz, Rhineland Palatinate, Germany, named after the printer Johannes Gutenberg since 1946. J Neurophysiol 102(6):3673-88. J Neurosci 20:6950-6961. However, the mechanisms and cellular targets of TA modulation of locomotor activity are incompletely understood. Cell Tissue Res 325:175-87. eCollection 2018. J Comput Neurosci 34(2):211-29. Vierk R, Pflueger HJ, Duch C (2010) Postembryonic development of centrally generated flight motor patterns in the hawkmoth, Manduca sexta. OA generally enhances locomotor behaviors such as Drosophila larval crawling and flight, whereas TA decreases locomotor activity. Duch's work group at Mainz University is investigating dendritic structures and functions using the fruit fly Drosophila as a model organism. Development 140(3):606-16. Here we genetically remove dendrites in Drosophila motoneurons, followed by analysis of functional outcomes. Herrera-Valdez MA, McKiernan EC*, Berger SD*, Ryglewski S, Duch C, Crook S (2013) Relating ion channel expression, bifurcation structure, and diverse firing patterns in a model of an identified motor neuron. PNAS 111(50):18049-54. Kadas D, Ryglewski S, Duch C (2015) Transient BK outward current enhances motoneurone firing rates during Drosophila larval locomotion. J Neurosci 27(41):11122-31. Duch C 2 Affiliations . J Neurophysiol 79:361-370. Arbeitsgruppe/Research team Prof. Dr. C. Duch. Close affiliations . 2. Meseke M, Evers JF, Duch C (2009) Postembryonic dendritic remodeling of an identified neuron is accompanied by changes in synapse distribution and dendritic input computation. : +49 (0) 6131 / 39 - 21979 Fax: +49 (0) 6131 / 39 - 23 004. J Physiol J Physiol 590(Pt 4):809-25. Duch C (2006) Form and function of identified insect motoneurons.

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